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Antimicrobial Stewardship Implementation
In its broader holistic sense, antibiotic stewardship is the careful and responsible management of antibiotic resources in the interest of long-term sustainability. There is general consensus that antibiotic resistance development and spread can be curtailed by limiting antibiotic use, discouraging misuse, and reducing the burden of infectious disease.1 An optimally functioning antimicrobial stewardship program is instrumental in accomplishing these goals. It can have significant positive impacts on morbidity and mortality, (Fig. 1) and potentially reduce healthcare costs in the range of 20-35%.2,3 Importantly, it plays a critical role in broad-based, larger scale efforts to help preserve our antibiotic resources for future generations.
Fig. 1 Decreased mortality through appropriate antimicrobial therapy
Source: adapted from Kollef, M. et al. (1999) Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 115:462-74 (cited by the CDC, 12 Steps to Prevent Antimicrobial Resistance: Hospitalized Adults) [Presentation]4
- Lesprit, P. and Brun-Buisson, C. (2008) Hospital Antibiotic Stewardship. Curr Opin Infect Dis:21:344-9.
- Nowak, M.A. et al. (2012) Clinical and economic outcomes of a prospective antimicrobial stewardship program. Am J Health-Syst Pharm 69:1500-1508.
- Carling, P. et al. (2003) Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Cont Hosp Epidemiol: 24:699-706.
- Kollef, M. et al. (1999) Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 115:462-74 (As Cited by CDC 12 Steps to Prevent Antimicrobial Resistance: Hospitalized Adults) [Presentation])
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